Two‐dimensional Pure Isotropic Proton Solid State NMR

One key bottleneck of solid-state NMR spectroscopy is that 1H spectra organic solids are often very broad due to the presence a strong network dipolar couplings. We have recently suggested new approach tackle this problem. More specifically, we parametrically mapped errors leading residual broadening into second dimension and removed them in correlation experiment. In way pure isotropic proton (PIP) were obtained contain only shifts provide highest resolution available today rigid solids. Here, using deep-learning method, extend PIP dimension, for samples L-tyrosine hydrochloride ampicillin obtain high 1H-1H double-quantum/single-quantum spin-diffusion with significantly higher than corresponding at 100 kHz MAS, allowing identification previously overlapped peaks.